Thermo Fisher Scientific NMDA epsilon 2 Polyclonal Antibody
NMDA epsilon 2 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC, ELISA 등 다양한 응용 가능. 인간, 마우스, 랫트에 반응하며 Protein A로 정제된 고순도 항체. 신경계 연구 및 NMDA 수용체 관련 질환 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human NMDA epsilon 2 (amino acids 331–430) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 50% glycerol, 1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
NMDAR2B is a member of the N-methyl-D-aspartate (NMDA) class of ionotropic glutamate receptors. These receptors are involved in long-term potentiation, an activity-dependent increase in synaptic transmission efficiency associated with memory and learning. NMDAR2B plays a crucial role in neuronal development and has been implicated in central nervous system disorders such as Alzheimer’s disease, epilepsy, and ischemic neuronal cell death. Overexpression of the NR2B subunit enhances learning and memory, while reduced expression is linked to age-related memory impairment. Phosphorylation at Tyr1472 on NR2B increases NMDAR expression at the synapse, contributing to synaptic plasticity. Dysfunction of NMDAR2B is associated with epileptic encephalopathy and autosomal dominant mental retardation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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