Thermo Fisher Scientific Neurofascin Polyclonal Antibody
Neurofascin 단백질을 검출하기 위한 Rabbit Polyclonal Antibody. Western blot과 IHC(Paraffin)에 적합. 인간, 생쥐, 랫트 반응성. 고순도 Affinity chromatography 정제, 액상 형태로 제공. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NFASC (Accession O94856), corresponding to amino acid residues G1313–A1347 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2852076 |
Product Specific Information
Antibody detects endogenous levels of total NFASC.
Target Information
Neurofascin encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains.
The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development.
Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na⁺ (Nav) channels, which are clustered by interactions with cytoskeletal and scaffolding proteins including neurofascin, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin.
This protein links the AIS extracellular matrix to the intracellular cytoskeleton. Neurofascin undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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