Thermo Fisher Scientific PMCA1 Polyclonal Antibody
PMCA1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 다양한 종(인간, 마우스, 랫, 개)에 반응하며 WB, IHC, ICC, ELISA 등 다중 응용 가능. 고순도 Protein A 정제 및 안정적 액상 형태로 연구용 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC-P) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:5,000–1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Dog, Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human PMCA1, amino acids 351–450 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The calcium pump of the plasma membrane, termed PMCA ATPase, pumps calcium from the cytosol to the extracellular space. This membrane-bound enzyme is related to other ATPases including the SERCA ATPase and the sodium/potassium pump. Four different genes encode PMCA ATPase, and studies have revealed 20 isoforms generated by alternate splicing. Gene products 1 and 4 are expressed in most tissues, while products 2 and 3 are tissue-specific. In the pancreas, beta cells express only the 4b isoform, whereas alpha and gamma cells express both 4a and 4b isoforms. Different splice variants exhibit distinct affinities for calcium and calmodulin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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