Thermo Fisher Scientific c-Abl Recombinant Rabbit Monoclonal Antibody (10M9P9)
Recombinant Rabbit Monoclonal Antibody recognizing human c-Abl protein. Validated for WB and ELISA applications. Produced in HEK293 cells and purified via Protein A. Supplied in PBS with BSA and glycerol for stability. For research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:5,000
ELISA
- Tested Concentration: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 10M9P9 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1000–1130 of human c-Abl |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.225 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20 °C, Avoid freeze/thaw cycles |
Product Specific Information
Immunogen Sequence:
TAFIPLISTR VSLRKTRQPP ERIASGAITK GVVLDSTEAL CLAISRNSEQ MASHSAVLEA GKNLYTFCVS YVDSIQQMRN KFAFREAINK LENNLRELQI CPATAGSGPA ATQDFSKLLS SVKEISDIVQ R
Target Information
The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase implicated in cell differentiation, division, adhesion, and stress response.
Activity of c-Abl is negatively regulated by its SH3 domain; deletion of this domain converts c-Abl into an oncogene.
In chronic myelogenous leukemia (CML) and some acute lymphoblastic leukemias (ALL), the c-Abl gene undergoes a (9;22) translocation, forming the Philadelphia chromosome and generating the Bcr-Abl fusion protein.
c-Abl may also regulate DNA repair by activating proapoptotic pathways when DNA damage is irreparable.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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