Thermo Fisher Scientific IDO Polyclonal Antibody
IDO1 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, 인간·마우스·랫트 반응성. Western blot 검증 및 항원 친화 크로마토그래피 정제. 고순도(>95%) 액상 형태로 안정적 저장 가능.
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Thermo Fisher Scientific IDO Polyclonal Antibody
Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to residues in Human INDO |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803567 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
IDO1 is an intracellular heme-containing enzyme that catalyzes the oxidative cleavage of the indole ring of several important regulatory molecules such as tryptophan, serotonin, and melatonin. Through this reaction, IDO1 initiates the production of biologically active metabolites known as kynurenines.
IDO1 is widely expressed in various human tissues, macrophages, and dendritic cells (DCs). During inflammation, interferons (IFNs) act on specific receptors to induce IDO1 expression. The production of IFN-gamma and induction of IDO1 represent key antimicrobial mechanisms.
Degradation and depletion of tryptophan by IDO1 inhibit the growth of viruses, bacteria, and parasites. Moreover, IDO1 plays a crucial role in immunoregulation during infection, pregnancy, autoimmunity, transplantation, and neoplasia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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