Thermo Fisher Scientific RIN1 Polyclonal Antibody
RIN1 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot과 Immunocytochemistry에 사용 가능하며, 고순도 Affinity chromatography로 정제되었습니다. PBS/glycerol buffer에 보관되며 -20°C에서 안정적으로 저장됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human RIN1 (Accession Q13671), corresponding to amino acid residues T654–A704 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851244 |
Product Specific Information
This antibody detects endogenous levels of total RIN1 protein.
Target Information
Rit and its neuron-specific homologue, Rin, belong to a subfamily of Ras-related GTPases. Despite lacking a CAAX box or similar C-terminal lipidation motif, Rit and Rin are membrane-associated. They share 64% amino acid identity and a unique nine amino acid effector domain (DPTIEDAYK) that is 100% conserved between murine and human proteins. Although similar to Ras, Rit and Rin interact with Ras-binding proteins such as RalGDS, Rlf, and AF-6, but not with Raf kinases, RIN1, or the p110 subunit of PI3 kinase. These findings suggest that Rit and Rin regulate signaling pathways distinct from those controlled by Ras.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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