Thermo Fisher Scientific CYP2A6 Polyclonal Antibody
CYP2A6 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간, 생쥐, 랫트 시료에서 반응하며 Western blot 및 IHC에 사용 가능. 약물 대사 관련 연구에 적합하며 안정적 액상 형태로 제공.
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Thermo Fisher Scientific CYP2A6 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 | - |
| Immunohistochemistry (IHC) | - | 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Purified, His-tagged, full length human P450 2A6 fusion protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2230297 |
Product Specific Information
PA1-342 detects cytochrome P450 (P450) 2A6 from human, mouse, and rat samples. This antibody detects, to a lesser extent, other P450 isoforms.
It has been successfully used in Western blot procedures, detecting an ~49 kDa protein representing P450 2A6 from rat liver extract.
The immunogen used is purified, His-tagged, full length human P450 2A6 fusion protein.
Target Information
The CYP2A6 gene encodes a member of the cytochrome P450 superfamily of enzymes. These proteins are monooxygenases that catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids.
CYP2A6 localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme hydroxylates coumarin and metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals.
Individuals with certain allelic variants exhibit poor metabolizer phenotypes, showing reduced metabolism of coumarin or nicotine.
This gene is part of a large cluster of cytochrome P450 genes (CYP2A, CYP2B, CYP2F subfamilies) on chromosome 19q and was formerly referred to as CYP2A3, now renamed CYP2A6.
Usage Restriction
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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