Thermo Fisher Scientific Factor X/Xa Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:1,000

Species Reactivity

• Human
• Mouse
• Rat

Host / Isotype

• Rabbit / IgG

Class

• Polyclonal

Type

• Antibody

Immunogen

Synthetic peptide corresponding to amino acids 1–50 of Human F10.

Conjugate

• Unconjugated

Form

• Liquid

Concentration

• 1 mg/mL

Purification

• Antigen affinity chromatography

Storage Buffer

• PBS, pH 7.2, with 50% glycerol

Contains

• 0.02% sodium azide

Storage Conditions

• Store at 4°C for short term
• For long-term storage, store at -20°C
• Avoid freeze/thaw cycles

Shipping Conditions

• Wet ice

RRID

• AB_2803692

Product Specific Information

• Purity >95% by SDS-PAGE

Target Information

Factor X undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. The two chains are held together by one or more disulfide bonds; the light chain contains two EGF-like domains, while the heavy chain contains the catalytic domain homologous to other hemostatic serine proteases. The mature factor is activated by cleavage of the activation peptide by factor IXa (intrinsic pathway) or factor VIIa (extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca²⁺, and phospholipid during blood clotting. Mutations in this gene result in factor X deficiency, a hemorrhagic condition of variable severity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.