Thermo Fisher Scientific PCBP1 Monoclonal Antibody (OTI3D12)
Thermo Fisher Scientific PCBP1 단일클론 항체(OTI3D12)는 인간 PCBP1 단백질(aa 1-225)에 특이적으로 반응하며 Western blot 및 IHC에 적합합니다. 1 mg/mL 농도의 액상 항체로, BSA와 글리세롤이 포함된 PBS buffer에 보관됩니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3D12 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–225 of PCBP1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2724952 |
Target Information
This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. PCBP1 and PCBP2 have paralogues that likely arose from duplication events of entire genes. The encoded protein is multifunctional and, along with PCBP2 and hnRNPK, corresponds to major cellular polydomains involved in RNA binding. Together with PCBP2, it functions as a translational coactivator of poliovirus RNA via sequence-specific interaction with stem-loop IV of the IRES and promotes poliovirus RNA replication by binding to its 5′-terminal cloverleaf structure. It is also implicated in translational control of 15-lipoxygenase mRNA, HPV type 16 L2 mRNA, and hepatitis A virus RNA. Additionally, it may contribute to formation of a sequence-specific alpha-globin mRNP complex associated with alpha-globin mRNA stability.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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