Thermo Fisher Scientific PD-L1 Monoclonal Antibody (OTI4D4), TrueMAB
인간 PD-L1(CD274)을 표적으로 하는 Mouse IgG1 단클론 항체로, Western blot, ELISA, Luminex 등 다양한 분석에 적합. 1 mg/mL 농도의 액상 형태이며 PBS/BSA/glycerol 저장 버퍼 사용. 종양 면역 회피 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:4,000
ELISA
- Tested Dilution: Assay-dependent
Luminex
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4D4 |
| Immunogen | Full length human recombinant protein of human CD274 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a recently described B7 family member. One specific receptor, programmed death receptor 1 (PD-1), can be ligated by PD-L1 and negatively regulates T-cell receptor (TCR) signaling. Upon ligation, PD-L1 decreases TCR-mediated proliferation and cytokine production. PD-L1 expression is abundant on many murine and human cancers and can be up-regulated by IFN-gamma stimulation. Thus, PD-L1 plays an important role in tumor immune evasion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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