Thermo Fisher Scientific Collagen II Polyclonal Antibody
Type II collagen을 인식하는 Rabbit Polyclonal Antibody로, Western blot 및 IHC(Frozen) 실험에 적합. Mouse와 Rat에 반응하며, 항원 친화 크로마토그래피로 정제됨. Lyophilized 형태로 제공되며 PBS/BSA 버퍼에 재구성 가능. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–0.5 µg/mL |
| Immunohistochemistry (Frozen) (IHC (F)) | 0.5–1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminus of mouse Collagen II (1222–1241aa, AFAGLGQREKGPDPMQYMRA) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with 5 mg BSA |
| Contains | 0.05 mg sodium azide, 0.05 mg thimerosal |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2746173 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
COL2A1 encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye.
Mutations in this gene are associated with:
- Achondrogenesis
- Chondrodysplasia
- Early onset familial osteoarthritis
- SED congenita
- Langer-Saldino achondrogenesis
- Kniest dysplasia
- Stickler syndrome type I
- Spondyloepimetaphyseal dysplasia Strudwick type
Defects in processing chondrocalcin, a calcium-binding protein that is the C-propeptide of this collagen molecule, are also linked to chondrodysplasia.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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