Thermo Fisher Scientific DFF45 Monoclonal Antibody (OTI5C4), TrueMAB
Western blot과 Immunocytochemistry에 적합한 DFF45 단클론 항체. 인간 ICAD 단백질을 인식하며, Mouse IgG1 형식의 TrueMAB 제품. 고순도 친화 크로마토그래피 정제, PBS/BSA/glycerol 완충액에 보관. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2500–1:5000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5C4 |
| Immunogen | Full length human recombinant protein of human DFFA produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
ICAD (Inhibitor of Caspase-3-Activated DNase) is a substrate that regulates nuclear apoptosis. It has two isoforms:
- ICAD-L/DFF45 (45 kDa): functional isoform
- ICAD-S/DFF35 (35 kDa): non-functional isoform
ICAD binds and inhibits CAD (Caspase-Activated DNase). Upon caspase-3 activation, ICAD is cleaved at residues 117 and 224, releasing CAD to perform apoptotic DNA fragmentation. ICAD also functions as a CAD-specific folding chaperone.
Recent studies suggest ICAD as a potential target for restoring normal apoptotic signaling in colon and brain cancer cells. Two alternatively spliced transcript variants encoding distinct isoforms have been identified for the ICAD gene.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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