Thermo Fisher Scientific MMP2 Recombinant Rabbit Monoclonal Antibody (5I2G1)
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카탈로그 번호 | CAS 번호 | 설명 | 상태 | 단위 | 판매가 | 할인가 | 가격(VAT포함) | 수량 / 장바구니 / 찜 |
MA551504 | - | Thermo Fisher Scientific MA551504 MMP2 Recombinant Rabbit Monoclonal Antibody (5I2G1) 100 ul pk | 재고문의 | pk | 0원 | - | 0원 |
Applications
Tested Dilution
Publications
Western Blot (WB)
1:1,000-1:2,000
ELISA (ELISA)
1 µg/mL
Product Specifications
Species Reactivity
Human, Mouse, Rat
Host/Isotype
Rabbit / IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
5I2G1
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 451-660 of human MMP2(NP_004521.1). if (typeof window.$mangular === undefined
|| !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{
targetFamily:
MMP2,
uniProtId:
P08253-1,
ncbiNodeId:
9606,
antigenRange:
451-660,
antigenLength:
660,
antigenImageFileName:
MA5-51504_MMP2_P08253-1_Rabbit.svg,
antigenImageFileNamePDP:
MA5-51504_MMP2_P08253-1_Rabbit_PDP.jpeg,
sortOrder:
1}\]
; $mangular.isB2BCMGT = false
; $mangular.isEpitopesModalImageMultiSizeEnabled = true
;
View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}
Conjugate
Unconjugated Unconjugated Unconjugated
Form
Liquid
Concentration
0.55 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_3094202
Product Specific Information
Immunogen sequence: ATTGACCTTG GCACCGGCCC CACCCCCACG CTGGGCCCTG TCACTCCTGA GATCTGCAAA CAGGACATTG TATTTGATGG CATCGCTCAG ATCCGTGGTG AGATCTTCTT CTTCAAGGAC CGGTTCATTT GGCGGACTGT GACGCCACGT GACAAGCCCA TGGGGCCCCT GCTGGTGGCC ACATTCTGGC CTGAGCTCCC GGAAAAGATT GATGCGGTAT ACGAGGCCCC ACAGGAGGAG AAGGCTGTGT TCTTTGCAGG GAATGAATAC TGGATCTACT CAGCCAGCAC CCTGGAGCGA GGGTACCCCA AGCCACTGAC CAGCCTGGGA CTGCCCCCTG ATGTCCAGCG AGTGGATGCC GCCTTTAACT GGAGCAAAAA CAAGAAGACA TACATCTTTG CTGGAGACAA ATTCTGGAGA TACAATGAGG TGAAGAAGAA AATGGATCCT GGCTTCCCCA AGCTCATCGC AGATGCCTGG AATGCCATCC CCGATAACCT GGATGCCGTC GTGGACCTGC AGGGCGGCGG TCACAGCTAC TTCTTCAAGG GTGCCTATTA CCTGAAGCTG GAGAACCAAA GTCTGAAGAG CGTGAAGTTT GGAAGCATCA AATCCGACTG GCTAGGCTGC
Target Information
MMP (matrix metalloproteinase) are proteolytic enzymes capable of degrading connective tissue components. MMP have a common mode of activation, a conserved amino acid sequence in the putative metal binding-active site region, and are inhibited by specific tissue inhibitors of metalloproteinases (TIMPs). MMPa and TIMPs play a significant role in regulating angiogenesis. MMP2 is synthesized as a 631 amino acid proenzyme which is activated by cleavage of the first 80 amino acids, and contains the basic structure of propeptide, catalytic, and hemopexin domains. The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane-bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non-fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc-binding site characterizes the structure of the MMPs. Functionally, MMP2 is involved in tissue remodeling. Mutations in MMP-2 gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms of MMP-2 have been found.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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