Thermo Fisher Scientific SKIL Monoclonal Antibody (OTI2F6), TrueMAB
SKIL 단백질을 표적하는 OTI2F6 클론의 Mouse IgG1 단일클론 항체로, Human, Mouse, Rat, Dog에 반응합니다. Western blot 및 IHC(P) 검증 완료. Lyophilized 형태이며 PBS buffer에 trehalose 함유. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2F6 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 307–684 of human SKIL produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis.
This signaling is negatively regulated by Ski and SnoN. SnoN binds to Smad proteins, preventing their phosphorylation and subsequent DNA binding, thus inhibiting transcriptional activation of downstream genes.
In cancer tissues or cells, SnoN is mainly nuclear, while in normal tissues or primary epithelial cells, it is cytoplasmic.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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