Thermo Fisher Scientific CD85g (ILT7) Monoclonal Antibody (eBio17G10.2 (17G10.2)), PerCP-Cyanine5.5, eBioscience
인간 ILT7(CD85g)을 인식하는 마우스 모노클로날 항체로, PerCP-Cyanine5.5 형광 표지. 플라스마사이토이드 수지상세포(pDC) 분석용으로 적합하며, 유세포분석(Flow Cytometry)에 최적화됨. 4°C 암소 보관, 동결 금지.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Flow Cytometry (Flow) | 5 µL (0.25 µg)/test | View 1 publication |
| Functional Assay (Functional) | – | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1 |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PerCP-Cyanine5.5, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBio17G10.2 (17G10.2) |
| Conjugate | PerCP-Cyanine5.5 |
| Excitation / Emission Max | 489 / 679 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10734831 |
Additional Formats
Product Specific Information
Description:
The eBio17G10.2 monoclonal antibody reacts with human immunoglobulin-like transcript 7 (ILT7), also known as CD85g. ILT7 belongs to the leukocyte immunoglobulin-like receptor (LIR) family and forms a functional complex with FcεR1γ to transduce ITAM-mediated signals that negatively regulate TLR-induced type I IFN production in human plasmacytoid dendritic cells (pDCs). ILT7 is expressed exclusively on pDCs and absent in monocyte-derived DCs. Expression decreases upon IL-3 or CpG treatment.
Double staining of human PBMCs with eBio17G10.2 and anti-pDC marker BDCA2 shows nearly complete co-staining. Crosslinking ILT7 with this antibody reduces transcription of IFN-α1, IFN-α2, IFN-α4, and IFN-β.
Applications Reported:
This antibody is reported for use in flow cytometric analysis.
Applications Tested:
Pre-titrated and tested for flow cytometric analysis of normal human peripheral blood cells. Recommended usage is 5 µL (0.25 µg) per test in a final volume of 100 µL. Suitable for 10⁵–10⁸ cells/test.
Fluorescence Properties:
Excitation: 488 nm
Emission: 695 nm
Laser: Blue Laser
Filtration: 0.2 µm post-manufacturing filtered
Target Information
ILT7 is a plasmacytoid dendritic cell (pDC)-specific IgG-like transcript and a member of the leukocyte immunoglobulin-like receptor gene family. In complex with FcER1α, it transduces ITAM-mediated signals that negatively modulate type I IFN production by pDCs. ILT7 serves as a potential target to regulate type I IFN production, which plays a major role in viral infection, autoimmune diseases, and anti-cancer immunity. ILT7, together with CD123 and BDCA-2, can be used to identify or classify pDC subsets based on TLR expression and TLR-mediated immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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