Thermo Fisher Scientific PHD1 Monoclonal Antibody (OTI7H3)
Thermo Fisher Scientific의 PHD1 단클론 항체(OTI7H3)는 인간 EGLN2 단백질을 인식하며 Western blot 및 IHC(P) 실험에 적합합니다. 고순도 Affinity Chromatography 정제, 1 mg/mL 농도, 안정적 PBS/BSA/glycerol 버퍼 구성으로 연구용에 최적화된 제품입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7H3 |
| Immunogen | Full length human recombinant protein of EGLN2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2723460 |
Target Information
Prolyl hydroxylase domain proteins HIF PHD1, HIF PHD2, and HIF PHD3 (known as PHD1, PHD2, and PHD3 in rodents, respectively) can hydroxylate HIF-alpha subunits.
Hypoxia-inducible factor (HIF) is a transcriptional regulator important in oxygen homeostasis.
The prolyl hydroxylases catalyze the posttranslational formation of 4-hydroxyproline in HIF-alpha proteins.
HIF PHD1 is widely expressed, with highest levels in testis, functioning as a cellular oxygen sensor and playing a role in cell growth regulation.
It can localize to the nucleus or cytoplasm and is detected in hormone-responsive tissues such as normal and cancerous mammary, ovarian, and prostate epithelium.
HIF PHD1 is encoded by EGLN2, which maps to chromosome 19q13.3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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