Thermo Fisher Scientific Cathelicidin Polyclonal Antibody

Applications

• Western Blot (WB): 10–50 µg/mL
• Immunohistochemistry (IHC): 10–50 µg/mL

Product Specifications

Product Specific Information

• Reconstitute with 500 µL of distilled water.
• OSC00028G can be used with blocking peptide GSC00002P.

Target Information

Cathelicidin is an epithelial-derived antimicrobial protein found in specific granules of polymorphonuclear leukocytes of bone marrow, testis, and neutrophils. Cathelicidins are a family of antimicrobial peptides characterized by conserved pro-peptide sequences identified in epithelial tissues and some myeloid cells of humans and animals. LL-37/hCAP-18 is the only Cathelicidin found in humans and is expressed in inflammatory and epithelial cells. These molecules are essential for defense against invasive bacterial infection in skin.

Besides their direct antimicrobial function, Cathelicidins have multiple roles in mediating innate and adaptive immunity, such as endotoxin neutralization, angiogenesis, wound healing, and promoting neutrophil chemotaxis and mast cell recruitment. Cathelicidin antimicrobial peptides qualify as prototypes of innovative drugs that may be used to treat infection and/or modulate the immune response.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.