Thermo Fisher Scientific RAP1GAP Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Positive Control: mouse brain, rat brain
• Predicted Reactivity: Human (81%), Bovine (80%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Rap1GAP specifically stimulates GTP hydrolytic activity of the monomeric G protein Rap1.
Physical interaction between G alpha z, a member of the Gi family of trimeric G proteins, and Rap1GAP blocks the ability of regulators of G protein signaling to stimulate GTP hydrolysis of the alpha subunit, and attenuates the ability of activated G alpha z to inhibit adenylyl cyclase.
Rap1GAP is expressed in the brain, kidney, and pancreas, and may act as a signal integrator to coordinate Gz signaling and Rap1 signaling in cells.
A novel isoform, Rap1GAPII, binds specifically to G alpha z. Stimulation of the Gi-coupled M2 Muscarinic receptor translocates Rap1GAPII from the cytosol to the membrane and decreases GTP-bound Rap1, resulting in activation of ERK/MAPK.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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