Thermo Fisher Scientific RAP1GAP Polyclonal Antibody
RAP1GAP 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC 등 다양한 실험에 사용 가능. Mouse와 Rat 반응성, 높은 특이성과 순도 확보. 연구용으로 신뢰성 높은 결과 제공.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:1,000 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the C-terminus region of mouse Rap1GAP (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol, 1% BSA |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2736497 |
Product Specific Information
- Positive Control: mouse brain, rat brain
- Predicted Reactivity: Human (81%), Bovine (80%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Rap1GAP specifically stimulates GTP hydrolytic activity of the monomeric G protein Rap1.
Physical interaction between G alpha z, a member of the Gi family of trimeric G proteins, and Rap1GAP blocks the ability of regulators of G protein signaling to stimulate GTP hydrolysis of the alpha subunit, and attenuates the ability of activated G alpha z to inhibit adenylyl cyclase.
Rap1GAP is expressed in the brain, kidney, and pancreas, and may act as a signal integrator to coordinate Gz signaling and Rap1 signaling in cells.
A novel isoform, Rap1GAPII, binds specifically to G alpha z. Stimulation of the Gi-coupled M2 Muscarinic receptor translocates Rap1GAPII from the cytosol to the membrane and decreases GTP-bound Rap1, resulting in activation of ERK/MAPK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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