Thermo Fisher Scientific CDK9 Monoclonal Antibody (K.513.1)
CDK9 단백질을 인식하는 Rabbit monoclonal antibody (Clone K.513.1). Western blot, IHC, ICC, Flow cytometry, IP에 사용 가능. 다양한 종에 반응하며, 고순도의 affinity chromatography로 정제. 세포 성장 및 전사 조절 연구에 적합.
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- MA514912
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 3 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:400 | - |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 | - |
| Flow Cytometry (Flow) | 1:100–1:400 | - |
| Immunoprecipitation (IP) | 1:100 | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Dog, Hamster, Human, Mouse, Non-human primate, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | K.513.1 |
| Immunogen | Synthetic peptide corresponding to residues near the carboxy terminus of human CDK9 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 163 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10986858 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
CDK9 is a serine/threonine kinase that forms an active holoenzyme complex with Cyclin T1, playing a key role in regulating the eukaryotic cell cycle. It regulates cytokine-inducible transcription networks by facilitating promoter recognition of target transcription factors and promotes RNA synthesis in genetic programs for cell growth, differentiation, and viral pathogenesis.
The CDK9/Cyclin-K complex also has kinase activity toward the CTD of RNAPII and can substitute for CDK9/Cyclin-T P-TEFb in vitro. Chronic activation of CDK9 may cause cardiac myocyte enlargement leading to cardiac hypertrophy and predisposition to heart failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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