Thermo Fisher Scientific NeuN Monoclonal Antibody (5A4B9)
NeuN 단일클론 항체(5A4B9)는 인간 및 생쥐 신경세포 마커 탐지를 위한 고특이성 항체입니다. Western blot, ICC/IF, Flow cytometry, ELISA 등 다양한 응용에 사용 가능하며, Protein G로 정제된 액상 형태로 제공됩니다. 장기보관은 -20°C에서 권장됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5A4B9 |
| Immunogen | Purified recombinant fragment of human RBFOX3 (AA: 1–140) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_3093302 |
Target Information
Fox-3, also known as NeuN, HRNBP3, or RBFOX3 (RNA binding protein, fox-1 homolog C), is a 350 amino acid protein containing one RRM (RNA recognition motif) domain. It is localized to both the nucleus and cytoplasm and is suggested to regulate alternative splicing events. Fox-3 is encoded by a gene located on human chromosome 17, which encompasses over 2.5% of the human genome and encodes more than 1,200 genes.
Chromosome 17 also includes two key tumor suppressor genes, p53 and BRCA1:
- p53: Maintains cellular genetic integrity by controlling DNA repair and apoptosis. Loss or malfunction is linked to malignant cell growth and Li-Fraumeni syndrome.
- BRCA1: Involved in DNA repair and associated with early-onset breast and ovarian cancers, as well as cancers of the colon, prostate, and fallopian tubes.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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