Thermo Fisher Scientific PECAM1 Monoclonal Antibody (OTI4D1), TrueMAB
인간 PECAM1(CD31)을 인식하는 마우스 단클론항체로, Luminex 분석에 사용 가능. TrueMAB 형식으로 고순도 정제되어 있으며, 0.5 mg/mL 농도의 액상 제품. 혈관 및 면역세포 신호 연구용으로 적합.
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Thermo Fisher Scientific PECAM1 Monoclonal Antibody (OTI4D1), TrueMAB
Applications
- Luminex (LUM): Assay-Dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4D1 |
| Immunogen | Full length human recombinant protein of human PECAM1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with <5% trehalose |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling via dual immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Upon phosphorylation by associated kinases, these motifs provide docking sites for protein-tyrosine phosphatases.
CD31 is expressed ubiquitously within the vascular compartment, mainly at junctions between adjacent cells. Its N-terminal Ig-like domain mediates homophilic binding, playing a key role in cell-cell interactions.
CD31 functions in integrin-mediated adhesion, transendothelial migration, angiogenesis, apoptosis, immune regulation, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis, and thrombosis. It is a key regulatory molecule in the vascular system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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