Thermo Fisher Scientific Human Activin R1B (ALK-4) Fc Chimera Recombinant Protein

Applications

Western Blot (WB)

• Assay-dependent

ELISA (ELISA)

• Assay-dependent

Control (Ctrl)

• Assay-dependent

Product Specifications

Product Specific Information

Carrier-Free

Stock solutions can also be prepared at 50–100 µg/mL in appropriate sterile buffer.
Carrier protein such as 0.2–1% BSA or HSA can be added when preparing the stock solution.

Target Information

ACVR1B is a serine/threonine kinase involved in signal transduction and cellular communication.
Several truncated ACVR1B isoforms have been reported to be exclusively expressed in human pituitary tumors.
Mutations of ACVR1B have been observed in pancreatic adenocarcinomas.
Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors.

ACVR1B encodes activin A type IB receptor, composed of 11 exons.
Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants.
The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.