Thermo Fisher Scientific P2Y14 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human P2Y14 receptor. Validated for IHC (paraffin) at 11 µg/mL. Antigen affinity purified, supplied in PBS with 0.1% sodium azide. Suitable for GPCR research and receptor signaling studies.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 11 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 17 amino acid peptide from 2nd extracellular domain of human P2RY14 / P2Y14 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551442 |
Product Specific Information
Percent identity with other species by BLAST analysis:
- Human: 100%
- Monkey: 94%
- Marmoset: 88%
Target Information
GPR105 (P2Y14) has been reported to be expressed in the brain. ESTs have been isolated from kidney, placenta, uterus, and heart/melanocyte/uterus libraries.
G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices and exist in both active and inactive forms.
An array of activating ligands participate in GPCR conformational changes, leading to signaling via G-proteins and downstream effectors. Studies have revealed complex mechanisms involved in the negative regulation of GPCRs, which are crucial for cellular physiological responses and pharmacological research targeting new drug candidates.
Two well-known GPCR-targeted pharmaceuticals include Zyprexa (Eli Lilly) and Claritin (Schering-Plough), both major drugs in mental health and allergy markets, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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