Thermo Fisher Scientific DDX58 Monoclonal Antibody (OTI8D2), TrueMAB

Thermo Fisher Scientific DDX58 Monoclonal Antibody (OTI8D2), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform desalting using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).

Target Information

Retinoic acid-inducible gene I (RIG-I) is a pattern recognition receptor (PRR) that detects viral double-stranded RNA (dsRNA) and initiates innate immune responses.

• Works alongside MDA5 in recognizing viral RNA.
• Activated by short dsRNAs lacking a 5′-triphosphate end.
• Signals through IPS-1 to activate NF-κB and IRF-3, leading to apoptosis and cytokine signaling.
• Plays a key role in responses to influenza A/B, RSV, paramyxoviruses, Japanese encephalitis virus, and West Nile virus.
• MicroRNA-146a negatively regulates RIG-I targets (TRAF6, IRAK1, IRAK2) for feedback inhibition.
• Recent evidence links RIG-I to cytosolic DNA detection via RNA polymerase III.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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