Thermo Fisher Scientific HOMER3 Polyclonal Antibody
HOMER3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC 등 다양한 응용에 적합. 고순도 항원 친화 크로마토그래피 정제. 인간 및 설치류 반응성. 연구용으로만 사용 가능.
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Thermo Fisher Scientific HOMER3 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to amino acids 55–305 of Homer3 (Uniprot ID: Q9NSC5) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris Glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Wet ice |
| RRID | AB_11151968 |
Product Specific Information
- Recommended positive control: NT2D1
- Predicted reactivity: Mouse (85%), Rat (86%), Rhesus Monkey (98%)
- IHC (P): Suggested antigen retrieval using heat-mediated 10 mM Citrate buffer (pH 6.0) or Tris-EDTA buffer (pH 8.0)
- Store product as a concentrated solution. Centrifuge briefly before opening the vial.
Target Information
HOMER3 encodes a member of the HOMER family of postsynaptic density scaffolding proteins. These proteins share a domain structure consisting of:
- N-terminal Enabled/VASP homology 1 domain (mediates protein-protein interactions)
- C-terminal coiled-coil domain and leucine zipper motifs (involved in self-oligomerization)
The encoded protein interacts with:
- Group I metabotropic glutamate receptors
- Inositol 1,4,5-trisphosphate receptors
- Amyloid precursor proteins
It is implicated in neuronal signaling, T-cell activation, and trafficking of amyloid beta peptides. Alternative splicing results in multiple transcript variants.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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