Thermo Fisher Scientific GGCX Polyclonal Antibody
Human GGCX 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P)에서 1:20–1:50 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS(40% glycerol) 내 보관. 비타민 K 의존성 단백질 연구에 적합.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:20–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human GGCX. Recombinant protein control fragment (Product #RP-91226) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2641977 |
Product Specific Information
Immunogen sequence:
FPGLHLENFV SEDLGNTSIQ LLQGEVTVEL VAEQKNQTLR EGEKMQLPAG EYHKVYTTSP SPSCYMYVYV NTTELALEQD LAYLQELKEK VENGSETGPL PPELQPLLEG EVK
Highest antigen sequence identity to the following orthologs:
- Mouse: 96%
- Rat: 97%
Target Information
GGCX (gamma-glutamyl carboxylase), also known as GC or VKCFD1 (Vitamin K-dependent gamma-carboxylase), is a 758 amino acid multi-pass membrane protein localized to the endoplasmic reticulum membrane.
It mediates vitamin K-dependent carboxylation of glutamate residues on target proteins, producing calcium-binding gamma-carboxyglutamate (Gla) residues and converting vitamin K to vitamin K epoxide.
GGCX functions as a monomer and is essential for post-translational modification of vitamin K-dependent proteins such as blood coagulation and bone matrix proteins.
Defects in GGCX cause combined deficiency of vitamin K-dependent clotting factors 1 (VKCFD1) and PXE-like disorder with multiple coagulation factor deficiency, leading to abnormalities in skin, blood, or bone function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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