Thermo Fisher Scientific ROS1 Monoclonal Antibody (OTI1F3), TrueMAB
ROS1 단백질을 표적하는 Mouse IgG1 단일클론 항체로, WB, IHC, ICC/IF 등 다양한 응용에 적합. 인간 ROS1 아미노산 2126-2347 구간을 면역원으로 제작. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:5,000 |
| Immunocytochemistry (ICC/IF) | 1:5,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1F3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 2126–2347 of human ROS1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
ROS1 is a tyrosine kinase that functions as a growth or differentiation factor receptor. Protein kinases transfer phosphate groups from ATP to substrate proteins, mediating signal transduction in eukaryotic cells. This regulation affects metabolism, transcription, cell cycle progression, cytoskeletal rearrangement, cell movement, apoptosis, and differentiation.
The protein kinase family comprises over 500 members, classified into eight major groups based on catalytic domain sequence comparison. Tyrosine kinases (TKs) primarily regulate cell-cell interactions such as differentiation, adhesion, motility, and death. Approximately 90 TK genes have been sequenced: 58 receptor TKs (e.g., EGFR, EPH, FGFR, PDGFR, TRK, VEGFR families) and 32 cytosolic TKs (e.g., ABL, FAK, JAK, SRC families).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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