Thermo Fisher Scientific Apolipoprotein J Recombinant Rabbit Monoclonal Antibody (2A1)
인간 Clusterin 유래 합성 펩타이드로부터 제작된 재조합 토끼 단클론 항체. IHC(P) 및 ELISA에 적합하며, 고순도 친화 크로마토그래피 정제. 세포 보호 및 단백질 응집 억제 연구에 활용 가능. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 2A1 |
| Immunogen | A synthesized peptide derived from human Clusterin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_3092752 |
Target Information
Isoform 1 functions as an extracellular chaperone that prevents aggregation of nonnative proteins and stress-induced aggregation of plasma proteins. It inhibits amyloid fibril formation by several aggregation-prone proteins (APP, APOC2, B2M, CALCA, CSN3, SNCA, LYZ variants) in vitro, without requiring ATP. It maintains partially unfolded proteins for refolding by chaperones such as HSPA8/HSC70. The secreted isoform protects cells from apoptosis and complement-mediated cytolysis. Intracellular isoforms interact with ubiquitin and SCF E3 ligase complexes to promote proteasomal degradation of target proteins, modulate NF-kappa-B activity, and regulate apoptosis and cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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