Thermo Fisher Scientific SCUBE2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human SCUBE2. Recombinant protein control fragment (Product #RP-88796). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SCUBE2,uniProtId:Q9NQ36-1,ncbiNodeId:9606,antigenRange:476-614,antigenLength:999,antigenImageFileName:PA5-56278_SCUBE2_Q9NQ36-1_Rabbit.svg,antigenImageFileNamePDP:PA5-56278_SCUBE2_Q9NQ36-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2647039

Product Specific Information

Immunogen sequence: SGIHLSSDVT TIRTSVTFKL NEGKCSLKNA ELFPEGLRPA LPEKHSSVKE SFRYVNLTCS SGKQVPGAPG RPSTPKEMFI TVEFELETNQ KEVTASCDLS CIVKRTEKRL RKAIRTLRKA VHREQFHLQL SGMNLDVAK

Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 83%.

Target Information

SCUBE2 is a member of a family of secreted glycoproteins that contain N-terminal EGF-like repeats and C-terminal cysteine-rich motifs and CUB domain and are expressed in embryonic neuroectoderm and vascular epithelium. SCUBE2 is a close homolog to SCUBE1 and can form a heterodimeric complex with SCUBE1. SCUBE2 is thought to participate in the Hedgehog signaling pathway by specifically interacting with Sonic Hedgehog (SHH) and the receptor PTCH1, enhancing the SHH signaling activity in the raft microdomains of the plasma membrane, and may thus play important roles in organ development and tumor progression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.