Thermo Fisher Scientific GUCY1A1 Polyclonal Antibody
Thermo Fisher Scientific의 GUCY1A1 Polyclonal Antibody는 인간, 마우스, 랫트 시료에 반응하는 토끼 유래 IgG 항체로, Western blot 및 IHC(P) 응용에 적합합니다. 합성 펩타이드 면역원으로 제작되었으며, 액상 형태로 -20°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-Dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human Guanylyl Cyclase alpha 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2691714 |
Product Specific Information
Predicted to react with Mouse and Rat samples.
Target Information
Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family.
There are two forms of guanylate cyclase:
- Soluble form (GCS or sGC) – acts as a receptor for nitric oxide
- Membrane-bound receptor form (GC) – acts as a peptide hormone receptor
The GC-C protein consists of:
- Extracellular domain
- Single transmembrane domain
- Cytoplasmic region (kinase-like + catalytic domains)
It is expressed as two glycosylated forms:
- 130 kDa precursor (endoplasmic reticulum)
- 145 kDa mature form (plasma membrane)
Ligand binding to the extracellular domain promotes cGMP accumulation.
GC-C acts as the receptor for heat-stable enterotoxins from pathogenic E. coli, causing secretory diarrhea, and also binds guanylin and uroguanylin peptides that modulate renal function in response to salt load.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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