Thermo Fisher Scientific HLA-DR Monoclonal Antibody (TU36), PE-Cyanine5.5

Applications

• Flow Cytometry (Flow)
  Tested Dilution: Assay-Dependent
  View 4 publications

Product Specifications

Additional Formats Available

• APC
• FITC
• Pacific Blue
• Pacific Orange
• PE
• PE-Texas Red
• PerCP
• Qdot 605
• Qdot 655
• Qdot 705
• Custom conjugation available upon request

Product Specific Information

The R-phycoerythrin (PE)-Cy5.5 tandem conjugate enables simultaneous multicolor labeling and detection of multiple targets using a single excitation source—the 488 nm line of the argon-ion laser.

Target Information

HLA-DR is a transmembrane glycoprotein belonging to the MHC class II family, composed of a 36 kDa alpha chain (DRA) and a 27 kDa beta chain (DRB).

• The alpha chain gene contains 5 exons:
  • Exon 1 encodes the leader peptide
  • Exons 2 and 3 encode extracellular domains
  • Exon 4 encodes the transmembrane domain and cytoplasmic tail
• DRA acts as the sole alpha chain for DRB1, DRB3, DRB4, and DRB5, lacking polymorphisms in the peptide-binding region.
• The DRB beta chain contains polymorphisms determining peptide-binding specificity.
• HLA-DR is expressed primarily on antigen-presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells, and activated T lymphocytes.
• DR, DQ, and DP loci encode the major expressed products of the human class II region.
• MHC class II molecules bind intracellularly processed peptides, present them to T-helper cells, and play a critical role in initiating immune responses.

HLA and MHC antibodies are essential tools in Immunopeptidomics, supporting identification and characterization of neoantigens through high-performance liquid chromatography (HPLC) coupled with tandem mass spectrometry.

Classification

Analyte Specific Reagent

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