Thermo Fisher Scientific LRRC8A Polyclonal Antibody
LRRC8A 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot에 최적화되어 있으며 인간, 마우스, 랫트에 반응 예상. 세포 부피 조절 및 면역세포 발달 연구에 적합. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB)
Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 782–810 amino acids from the C-terminal region of human LRRC8A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2634665 |
Product Specific Information
Predicted to react with mouse and rat based on sequence homology.
Target Information
Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes.
The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes such as taurine.
It is unclear whether LRRC8A constitutes a pore-forming subunit or whether it is closely associated with the pore and mediates channel properties such as ion selectivity.
Involved in B-cell development: required for the pro-B cell to pre-B cell transition. Also required for T-cell development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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