Thermo Fisher Scientific PECAM1 Monoclonal Antibody (OTI1F9), TrueMAB
PECAM1 단백질을 인식하는 인간 반응성 마우스 단클론 항체로, Western blot과 IHC(Paraffin) 적용 가능. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공되며 CD31 연구용으로 적합. 연구용 전용 시약.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1F9 |
| Immunogen | Full length human recombinant protein of human PECAM1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling through dual immunoreceptor tyrosine-based inhibitory motifs (ITIM). Upon kinase-mediated phosphorylation, these motifs provide docking sites for protein-tyrosine phosphatases.
CD31 is expressed throughout the vascular compartment, primarily at junctions between adjacent cells. Its N-terminal Ig-like domain mediates homophilic binding, crucial for cell-cell interactions.
CD31 plays diverse roles in integrin-mediated adhesion, transendothelial migration, angiogenesis, apoptosis, immune regulation, macrophage phagocytosis, IgE-mediated anaphylaxis, and thrombosis, serving as a key regulatory molecule in the vascular system.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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