Thermo Fisher Scientific FPR3 Monoclonal Antibody (8A6G12)
FPR3 단백질을 인식하는 Thermo Fisher Scientific의 마우스 단클론 항체로, Western blot, IHC, Flow cytometry, ELISA 등 다양한 응용에 적합합니다. 인간 시료에 반응하며, 단백질 G로 정제된 액상 형태로 제공됩니다. 연구용 전용 제품입니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 8A6G12 |
| Immunogen | Purified recombinant fragment of human FPR3 expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C for short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3090854 |
Target Information
The N-formyl peptide receptor (FPR) family includes three members: FPR, FPR3 (also known as FPRL1, lipoxin A4 receptor, FPRH1, or FPR2), and FPR-like 2 (FPRL2). These are chemotactic G protein-coupled receptors with seven transmembrane domains, primarily expressed on phagocytic leukocytes such as neutrophils and monocytes. Each receptor has specific residues determining ligand specificity.
FPR3 is a promiscuous receptor that binds to multiple ligands, including lipoxin A4, N-formyl-methionyl-leucyl-phenylalanine (fMLP), serum amyloid A (SAA), prion peptide, and the 42-amino-acid form of beta amyloid. Upon activation, FPR3 induces migration and calcium mobilization in human monocytes and neutrophils, playing a role in inflammation and host defense responses. It may mediate inflammation in prion and Alzheimer’s diseases, making it a potential therapeutic target.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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