Thermo Fisher Scientific FGFR3 Monoclonal Antibody (1E3F9)
FGFR3 단백질을 인식하는 Mouse IgG2a 단일클론 항체로, Western blot, IHC, ICC, Flow cytometry, ELISA 등에 사용 가능. 인간 시료 반응성. 단백질 G로 정제된 액상 형태로 제공되며, 1 mg/mL 농도. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (IHC) | 1:200–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:250 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1E3F9 |
| Immunogen | Purified recombinant fragment of human FGFR3 (AA: 529–694) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3090768 |
Target Information
FGFR3 (Fibroblast Growth Factor Receptor 3) is a member of the FGFR family of receptor tyrosine kinases. This family regulates various cellular functions such as angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, differentiation, and tissue repair. FGFR family members differ in ligand affinity and tissue distribution and are implicated in diseases including cancer, rheumatoid arthritis, and diabetic retinopathy.
FGFR3 consists of:
- An extracellular region with three immunoglobulin-like domains
- A hydrophobic membrane-spanning segment
- A cytoplasmic tyrosine kinase domain
The extracellular region interacts with fibroblast growth factors, triggering downstream signaling pathways that influence cell proliferation and differentiation. FGFR3 plays an essential role in bone development and maintenance. Mutations in FGFR3 are associated with craniosynostosis and various skeletal dysplasias. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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