Thermo Fisher Scientific ABCB11 Polyclonal Antibody
ABCB11 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF에 사용 가능하며 Human, Mouse, Rat에 반응. Affinity chromatography로 정제된 액상형 제품으로, -20°C에서 보관. 연구용 전용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ABCB11 (Accession O95342), corresponding to amino acid residues N665–V715 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2899436 |
Product Specific Information
Antibody detects endogenous levels of total ABCB11.
Target Information
ABCB11 is involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. It is expressed predominantly in the liver, localized to the canalicular microvilli and subcanalicular vesicles of hepatocytes. Structurally, ABCB11 is a multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP-binding cassette (ABC) domain.
Defects in ABCB11 cause progressive familial intrahepatic cholestasis 2 (PFIC2), an inherited liver disease of childhood characterized by cholestasis and normal serum gamma-glutamyltransferase activity. Defects are also associated with chronic intrahepatic cholestasis without a familial history of liver disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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