Thermo Fisher Scientific ASK1 Polyclonal Antibody
ASK1 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal 항체로, 인간·마우스·랫트 시료에 반응합니다. IHC(P) 등 다양한 응용에 적합하며, 고순도(>95%)로 정제된 액상 제품입니다. 장기 보관은 -20°C에서 권장됩니다.
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 924–978 of Human ASK1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2802908 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
MAP3K5 (ASK1) is a serine/threonine kinase abundantly expressed in human heart and pancreas and activated in response to various extracellular stimuli including cytokines, growth factors, and environmental stresses. ASK1 (apoptosis signal-regulating kinase 1) activates two subgroups of MAPKK, MKK4 and MKK6, which in turn activate JNK and p38 MAP kinase, respectively. ASK1/MAPKKK5 is activated by TNFR and Fas through interaction with TRAF family members and Fas-associated protein Daxx. Overexpression of ASK1 induces apoptotic cell death, while a catalytically inactive form inhibits TNF-α-induced apoptosis. ASK1 is expressed in various human and mouse tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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