Thermo Fisher Scientific Human RET [Y791F], GST Tag Recombinant Protein

Applications

• Kinase Assay (KA): Assay-dependent

Product Specifications

Product Specific Information

For maximum recovery, please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg, and 20 µg sizes of kinase are not recommended as materials can be used in original packaging until exhausted.
For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots; aliquots below 20 µL are not recommended.
Do not store kinase diluted.
If properly stored at -80°C, this product is guaranteed for 6 months from date of purchase.

Protein Form: Cytoplasmic

Target Information

The receptor tyrosine kinase RET is a member of the cadherin superfamily. RET plays a crucial role in neural crest development and can undergo oncogenic activation by cytogenetic rearrangement. RET transduces signals for cell growth and differentiation.
Mutations in the RET gene are associated with multiple endocrine neoplasia type IIA and IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for the RET gene, though additional variants exist with unconfirmed biological validity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.