Thermo Fisher Scientific ASH2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Rat, Chicken, Turkey, Bovine, Dog, Horse, Guinea pig, Panda, Orangutan, Monkey, Gorilla, Chimpanzee, and Green anole.

Target Information

The human ASH2L gene encodes a 628 amino acid protein (ASH2L1, isoform 1) containing a nuclear localization signal and a PHD finger motif, suggesting a role as a transcription regulator.

• Predicted molecular weight: 68.7 kDa
• Alternative splicing may produce isoforms at 60 kDa and 56.5 kDa.
• Human ASH2L shares 60% homology with Drosophila ash2 and 90% with mouse ASH2L.
• Expression is predominant in adult heart and testis, and in fetal lung and liver.
• Low expression is observed in adult lung, liver, kidney, prostate, and peripheral leukocytes.
• Expressed in leukemia cell lines (K562, Hel, Dami) with erythroid and megakaryocytic potential.
• Expression patterns vary with differentiation inducers (e.g., phorbol ester, hemin), suggesting a role in hematopoiesis and certain leukemia types.
• ASH2L may interact with beta-tubulin and beta-catenin.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.