Thermo Fisher Scientific ACE2 Monoclonal Antibody (OTI4D2), TrueMAB
인간 ACE2 단백질을 인식하는 마우스 단클론 항체로, Western blot 및 IHC(파라핀) 적용 가능. TrueMAB 형식으로 고순도 친화 크로마토그래피 정제. 동결건조 형태로 제공되며, 재구성 후 1 mg/mL 농도. 심혈관 및 바이러스 연구에 적합.
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Applications
- Western Blot (WB): 1:200
- Immunohistochemistry (Paraffin) (IHC(P)): 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4D2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 18–237 of human ACE2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of about 1 mg/mL.
For conjugation experiments, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Angiotensin-converting enzyme 2 (ACE2) plays a key role in vascular, renal, and myocardial physiology.
Unlike its homolog ACE, ACE2 expression is primarily found in the heart, kidney, and testis.
ACE2 also functions as a receptor for the SARS coronavirus.
It converts angiotensin I (AngI) to Ang1-9 and AngII to Ang1-7, differing from ACE, which converts AngI to AngII.
Deficiency of ACE2 in mice leads to reduced cardiac contractility, highlighting its importance in heart function regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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