Thermo Fisher Scientific OGG1 Polyclonal Antibody
OGG1 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체. Western blot과 IHC에 사용 가능하며, 인간·마우스·랫트 반응성. 합성 펩타이드 면역원 기반, 0.5 mg/mL 농도, -20°C 보관.
- 카탈로그번호
- PA518747
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 0.1–0.3 µg/mL
- Publications: [참고 문헌 없음]
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
- Publications: [참고 문헌 없음]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (HPKTSQAKGPSPLANK) corresponding to the internal amino acids of OGG1 (aa 282–297) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10985725 |
Product Specific Information
- This antibody is predicted to react with mouse based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
8-hydroxyguanine, a form of oxidative DNA damage induced by free radicals, causes G:C to T:A transversion.
In E. coli, three DNA repair enzymes exist to prevent the mutagenic effects of 8-hydroxyguanine. One of these enzymes, MutM, was found to have functional yeast (yOgg1) and human (hOgg1) homologues.
hOgg1 proteins efficiently release 8-hydroxyguanine opposite the pyrimidine from DNA and cleave the AP site similarly to bacterial and yeast enzymes.
Genetic backgrounds controlling the repair of damaged DNA are involved in susceptibility to cancer development. The hOgg1 gene has been mapped to region 3p26.2, showing loss of heterozygosity (LOH) in various cancers, particularly lung cancer (3p25–p26).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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