Thermo Fisher Scientific RIG-I Monoclonal Antibody (4G1B6)
RIG-I 단백질을 인식하는 Mouse Monoclonal Antibody (Clone 4G1B6). Western blot, ICC/IF, Flow Cytometry, ELISA, IP에 사용 가능. Human 시료 반응성. Protein G 정제, 1 mg/mL 농도. 단기 4°C, 장기 -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 2 publications |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 | - |
| Flow Cytometry (Flow) | 1:200–1:400 | - |
| ELISA | 1:10,000 | - |
| Immunoprecipitation (IP) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgM |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4G1B6 |
| Immunogen | Purified recombinant fragment of human DDX58 (AA: 789–925) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787339 |
Product Specific Information
MA5-31715 has been tested in indirect ELISA.
Target Information
Retinoic acid-inducible gene I (RIG-I) is a pattern recognition receptor (PRR) that recognizes viral double-stranded RNA (dsRNA). Along with MDA5, RIG-I detects viral RNA and activates innate immune responses.
RIG-I is activated by dsRNAs lacking a 5′-triphosphate end and short dsRNAs, whereas MDA5 responds to long dsRNAs. Upon activation, both signal through IPS-1 to activate transcription factors NF-κB and IRF-3, leading to apoptosis, cytokine signaling, and inflammation.
RIG-I is essential for immune signaling against influenza A/B, RSV, paramyxoviruses, Japanese encephalitis virus, and West Nile virus. MicroRNA-146a negatively regulates RIG-I–dependent antiviral responses by targeting TRAF6, IRAK1, and IRAK2.
Recent studies also suggest that RIG-I participates in cytosolic DNA detection via RNA polymerase III activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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