Thermo Fisher Scientific Human ADAP Synthetic Peptide

Thermo Fisher Scientific Human ADAP Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 20 amino acids near the carboxy terminus of human ADAP.
PEP-0517 can be used as a blocking peptide with polyclonal antibody PA5-20400.

Target Information

The adhesion and degranulation adaptor protein (ADAP) was initially identified as a molecular adapter that couples T cell receptor (TCR) stimulation to the avidity of integrins governing T cell adhesion.
TCR stimulation promotes the formation of a multi-protein complex containing CARMA1, MALT1, and BCL-10, which through the association of ADAP, ultimately activates the NF-kappa-B family of transcription factors.
Recent experiments have shown that ADAP controls optimal T cell proliferation, cytokine production, and expression of the Bcl-2 family member Bcl-x(L), suggesting that ADAP regulates T cell activation by promoting antigen-dependent T cell-antigen presenting cell (APC) activation.
At least three isoforms of ADAP are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.