Thermo Fisher Scientific HRX Monoclonal Antibody (10F8D7)
HRX 단백질을 타겟으로 하는 Thermo Fisher Scientific의 마우스 단클론 항체. Western blot, IHC, ELISA에 적합하며 인간 시료에 반응. 정제된 MLL 단백질 조각(aa3751–3968)을 면역원으로 사용. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 10F8D7 |
| Immunogen | Purified recombinant fragment of MLL (aa3751–3968) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Ascites |
| Contains | 0.03% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_10985776 |
Product Specific Information
MA5-15380 targets MLL in indirect ELISA, IHC, and WB applications and shows reactivity with human samples.
The immunogen is a purified recombinant fragment of MLL (aa3751–3968) expressed in E. coli.
Target Information
KMT2A is a histone methyltransferase essential for early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, which mediates methylation of Lys-4 of histone H3 (H3K4me) and acetylation of Lys-16 of histone H4 (H4K16ac).
In the MLL1/MLL complex, KMT2A specifically mediates H3K4me, an epigenetic activation mark. KMT2A alone has weak methyltransferase activity and requires other complex components for full activity. It has no activity toward histone H3 phosphorylated on Thr-3, less activity toward H3 dimethylated on Arg-8 or Lys-9, and higher activity toward H3 acetylated on Lys-9.
KMT2A is required for transcriptional activation of HOXA9 and promotes PPP1R15A-induced apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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