Thermo Fisher Scientific CD63 Monoclonal Antibody (OTI2G6), TrueMAB

Applications

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

CD63 (LAMP-3, lysosome-associated membrane protein-3) is a glycoprotein of the tetraspanin family found in late endosomes, lysosomes, and secretory vesicles. It also appears on the plasma membrane following cell activation and serves as a basophil activation marker.
In mast cells, CD63 expression does not require activation. It interacts with integrins and regulates phagocytosis, cell migration, and trafficking of H/K-ATPase and ROMK1 channels. CD63 also functions as a T-cell costimulatory molecule and is useful for prognosis prediction in early carcinoma stages.
CD63 is expressed on activated platelets, monocytes, macrophages, and weakly on granulocytes, B, and T cells. It is identical to melanoma-associated antigen ME491 and platelet antigen PTLGP40.
Diseases associated with CD63 dysfunction include melanoma and Hermansky-Pudlak Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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