Thermo Fisher Scientific MUC4 Polyclonal Antibody
MUC4 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC 등 다양한 응용에 사용 가능. 인간 MUC4 β chain 내부 영역을 면역원으로 제작. 높은 특이성과 재현성 제공. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:5,000 | - |
| Immunohistochemistry (IHC) | - | 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:400 | - |
| Immunocytochemistry (ICC/IF) | 1:250 | - |
Product Specifications
| Item | Description |
|---|---|
| Published species | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A partial recombinant protein made to an internal region of the human MUC4 protein beta chain (within residues 5150–5300). [Swiss-Prot Q99102] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152455 |
Product Specific Information
Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.
Target Information
Nearly all mucosal surfaces are protected by mucin transmembrane glycoproteins, from bronchioles to corneas to reproductive tracts.
Mucin 4 (MUC4) is membrane-bound and plays an important role in protection and lubrication of epithelial surfaces.
Aberrant MUC4 expression has been observed in various carcinomas and sarcomas, including fibromyoxoid sarcoma and pancreatic adenocarcinoma.
Immunohistochemical staining for MUC4 has been discussed as a potential biomarker for detection of these cancers.
MUC4 is also implicated in certain Asian diseases such as Taiwanese infertility, endometriosis, and gallstone formation in Chinese men, where similar diseases in other populations do not share these MUC4 mutations.
Because MUC4 is essential for mucosal surface protection, its failure has been associated with metastatic cancer invasions.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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