Thermo Fisher Scientific TREX1 Polyclonal Antibody
TREX1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot, IHC, IP 등 다양한 응용에 적합. 고순도 항원 친화 크로마토그래피로 정제된 액상 제품으로, 인간 단백질에 반응. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:200 |
| Immunoprecipitation (IP) | 1:200–1:2,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human Three-prime repair exonuclease 1 protein (1–270aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_2902342 |
Product Specific Information
This antibody has been tested in direct ELISA.
Target Information
Trex1 (ATRIP) is the major human 3′ to 5′ exonuclease required for checkpoint signaling after DNA damage. It is ubiquitously expressed and binds to single-stranded DNA coated with replication protein A that accumulates at sites of DNA damage, recruiting ATR kinase to these sites. Trex1 is essential for ATR expression.
This gene uses two different open reading frames:
- The upstream ORF encodes proteins interacting with ATR and localizing to intranuclear foci induced by DNA damage, essential for checkpoint signaling.
- The downstream ORF encodes proteins with 3′ to 5′ exonuclease activity and may be a subunit of human DNA polymerase III.
Multiple transcript variants encoding different isoforms have been identified. Mutations in this gene are associated with Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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