Thermo Fisher Scientific C1orf198 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Immunogen sequence:
ALKSSQGSRS SSLDALGPTR KEEEASFWKI NAERSRGEGP EAEFQSLTPS QIKSMEKGEK VLPPCYRQEP APKDREAKVE RPSTLRQEQR PLPNVSTERE RPQPVQAFSS ALHEAAPSQL EGKLPSPDVR QDDGEDTLFS EPKFAQ

Highest antigen sequence identity to the following orthologs:

• Mouse: 68%
• Rat: 66%

Target Information

Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinson’s, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.