Thermo Fisher Scientific IDO1 Monoclonal Antibody (OTI2B5), TrueMAB
IDO1 단백질을 표적하는 Mouse IgG1 단클론 항체로, WB, IHC, ICC 등 다양한 응용에 적합. 인간 시료 반응성 검증 완료. 고순도 친화 크로마토그래피 정제, 액상 형태로 안정적 보관 가능. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:4,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2B5 |
| Immunogen | Full length human recombinant protein of human IDO1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
IDO1 is an intracellular heme-containing enzyme that catalyzes the oxidative cleavage of the indole ring of several important regulatory molecules such as tryptophan, serotonin, and melatonin. This reaction initiates the production of biologically active metabolites known as kynurenines. IDO1 is expressed in various human tissues, macrophages, and dendritic cells (DCs). During inflammation, interferons (IFNs) induce IDO1 expression, contributing to antimicrobial defense mechanisms. Degradation of tryptophan by IDO1 inhibits the growth of viruses, bacteria, and parasites. Additionally, IDO1 plays a vital role in immunoregulation during infection, pregnancy, autoimmunity, transplantation, and neoplasia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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