Thermo Fisher Scientific IDO1 Monoclonal Antibody (OTI2A10), TrueMAB
IDO1 단백질을 인식하는 Mouse Monoclonal Antibody로 Western blot 및 Immunocytochemistry에 적합. HEK293T 세포에서 발현된 full-length human IDO1 항원을 면역원으로 사용. 고순도 Affinity chromatography 정제, PBS/BSA/glycerol 완충액 형태로 제공. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:4,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2A10 |
| Immunogen | Full length human recombinant protein of human IDO1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
IDO1 is an intracellular heme-containing enzyme that catalyzes the oxidative cleavage of the indole ring of several important regulatory molecules such as tryptophan, serotonin, and melatonin. This process leads to the production of biologically active metabolites known as kynurenines.
IDO1 is expressed in a wide range of human tissues, including macrophages and dendritic cells. During inflammation, interferons (IFNs) stimulate IDO1 induction, contributing to antimicrobial defense by degrading tryptophan, thereby inhibiting the growth of viruses, bacteria, and parasites.
Additionally, IDO1 plays a critical role in immunoregulation during infection, pregnancy, autoimmunity, transplantation, and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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